The Jacksonville Jaguars will be treated to some California heat when the Florida team faces the San Francisco 49ers on September 28.
Since 1999, both teams have faced off only seven times. The 49ers own a 5-2 record against the Jaguars, with the latter losing the last five matchups.
Can the 49ers overcome several obstacles heading into this Week 4 matchup? George Kittle has been out due to a hamstring injury, while quarterback Brock Purdy is dealing with a toe injury. Christian McCaffrey’s status will be in question following another setback early in the season.
BUY NOW: Get tickets to see 49ers vs. Jaguars on StubHub
It will be an interesting situation to monitor when the team plays in front of a loyal fanbase at Levi’s Stadium.
Meanwhile, a healthy Trevor Lawrence is ready to exceed expectations for the Jaguars. Two-way player Travis Hunter looks to continue his progression, while Travis Etienne has a chance to have a breakout season.
Here’s everything you need to know about this Week 4 matchup, including links to the best and most affordable tickets.
49ers vs. Jaguars tickets for Week 4 NFL game
Tickets for the 49ers vs. Jaguars game are available now on StubHub!
Ticket prices start at $110.
Prices then range from $200 to $5,679.
BUY NOW: Tickets for 49ers vs. Jaguars at Levi’s Stadium
49ers vs. Jaguars start time for 2025 Week 4 NFL game
- Date: Sunday, Sept. 28
- Time: 4:05 p.m. ET (1:05 p.m. PT)
The 49ers host the Jaguars in Week 4 of the 2025 NFL season. The game will kickoff at 4:05 p.m. ET (1:05 p.m. PT) on Sunday, Sept. 28.
The game will emanate from Levi’s Stadium in Santa Clara, California. The home of the 49ers can hold up to 68,500 people.
Levi’s Stadium seat map
Here’s the seating map for Levi’s Stadium:
Levi’s Stadium
San Francisco 49ers 2025-26 schedule
Below is a look at every game on San Francisco’s 2025 schedule. Click here for tickets to every matchup.
| Week | Date | Game | Time (ET)/Results |
| 1 | Sun., Sept. 7 | at Seahawks | W, 17-13 |
| 2 | Sun., Sept. 14 | at Saints | 1 p.m. |
| 3 | Sun., Sept. 21 | vs. Cardinals | 4:25 p.m. |
| 4 | Sun., Sept. 28 | vs. Jaguars | 4:05 p.m. |
| 5 | Thurs., Oct. 2 | at Rams | 8:15 p.m. |
| 6 | Sun., Oct. 12 | at Buccaneers | 1 p.m. |
| 7 | Sun., Oct. 19 | vs. Falcons | 8:20 p.m. |
| 8 | Sun., Oct. 26 | at Texans | 1 p.m. |
| 9 | Sun., Nov. 2 | at Giants | 1 p.m. |
| 10 | Sun., Nov. 9 | at Rams | 4:25 p.m. |
| 11 | Sun., Nov. 16 | at Cardinals | 4:05 p.m. |
| 12 | Mon., Nov. 24 | vs. Panthers | 8:15 p.m. |
| 13 | Sun., Nov. 30 | at Browns | 1 p.m. |
| 14 | BYE | – | – |
| 15 | Sun., Dec. 14 | vs. Titans | 4:25 p.m. |
| 16 | Mon., Dec. 22 | at Colts | 8:15 p.m. |
| 17 | Sun., Dec. 28 | vs. Bears | 8:20 p.m. |
| 18 | TBD | vs. Seahawks | TBD |
Jacksonville Jaguars 2025-26 schedule
Below is a look at every game on Jacksonville’s 2025 schedule. Click here for tickets to every matchup.
| Week | Date | Game | Time (ET)/Results |
| 1 | Sun., Sept. 7 | vs. Panthers | W, 26-10 |
| 2 | Sun., Sept. 14 | at Bengals | 1 p.m. |
| 3 | Sun., Sept. 21 | vs. Texans | 1 p.m. |
| 4 | Sun., Sept. 28 | at 49ers | 4:05 p.m. |
| 5 | Mon., Oct. 6 | vs. Chiefs | 8:15 p.m. |
| 6 | Sun., Oct. 12 | vs. Seahawks | 1 p.m. |
| 7 | Sun., Oct. 19 | vs. Rams | 9:30 a.m. |
| 8 | BYE | – | – |
| 9 | Sun., Nov. 2 | at Raiders | 4:05 p.m. |
| 10 | Sun., Nov. 9 | at Texans | 1 p.m. |
| 11 | Sun., Nov. 16 | vs. Chargers | 1 p.m. |
| 12 | Sun., Nov. 23 | at Cardxinals | 4:05 p.m. |
| 13 | Sun., Nov. 30 | at Titans | 1 p.m. |
| 14 | Sun., Dec. 7 | vs. Colts | 1 p.m. |
| 15 | Sun., Dec. 14 | vs. Jets | 1 p.m. |
| 16 | Sun., Dec. 21 | at Broncos | 4:05 p.m. |
| 17 | Sun., Dec. 28 | at Colts | 1 p.m. |
| 18 | TBD | vs. Titans | TBD |
