The San Francisco 49ers suffered their first loss of the season in Week 4 when they fell to the Jacksonville Jaguars, but that wasn’t the only issue to come out of the game.
Quarterback Brock Purdy, who returned to the field after missing the previous two weeks with an injury, reportedly aggravated the injury during the game. With San Francisco set to face the Los Angeles Rams on Thursday night, Purdy and the rest of the 49ers face a quick turnaround.
Here’s the latest on Purdy’s status for this week.
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Is Brock Purdy playing this week?
Purdy is not playing in Week 5.
Brock Purdy (toe), Ricky Pearsall (knee), Jauan Jennings (ankle, ribs) are out Thursday night vs. the Rams.
— Adam Schefter (@AdamSchefter) October 1, 2025
After San Francisco’s loss to the Jaguars, Purdy felt toe soreness that puts his status this week in question. The 49ers quarterback was listed as did not practice on Monday, as he wouldn’t have been able to participate if San Francisco had held a session.
“Anytime you have a Thursday game, it’s a totally different element,” he said, via ESPN. “So, I’m concerned with anybody who’s not totally healthy at this moment, but we’ll have to get more information on that later today to really have a clue of what to speculate.”
General manager John Lynch added early in the week that Purdy would be questionable for the game.
“We will take every precaution to make sure Brock’s all right,” Lynch said. “I think he is, now can he turn it around on a short week?”
#49ers GM John Lynch told @KNBR that QB Brock Purdy and Ricky Pearsall will both be questionable for the TNF #Rams game.
“We will take every precaution to make sure Brock’s all right. I think he is, now can he turn it around on a short week?”
— Ian Rapoport (@RapSheet) September 30, 2025
With Purdy sidelined, backup quarterback Mac Jones will make his third start of the season.
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Brock Purdy injury update
Purdy suffered a turf toe injury in Week 1 against the Seattle Seahawks, which forced him to miss the next two games. He was able to return to action in Week 4 as the 49ers hosted the Jaguars, but he felt toe soreness after the game.
However, after the 49ers’ game on Sunday, Purdy reportedly felt toe soreness that puts his status for this week in doubt.
From @NFLGameDay Kickoff: #49ers QB Brock Purdy, dealing with soreness, would not have practiced today. In a short week, that puts his status in question. pic.twitter.com/NXed8JBw8z
— Ian Rapoport (@RapSheet) September 29, 2025
After practice on Tuesday, Purdy spoke with the media and said, while he is sore, the injury isn’t as bad as it initially was after Week 1.
Brock Purdy said he is still a little sore but toe is a lot better than it was after Week 1. Here’s 90 seconds with the QB: pic.twitter.com/Vn0huJQEpy
— Vic Tafur (@VicTafur) September 30, 2025
Despite the expectation being that he would be questionable, Purdy was outright ruled out for Thursday’s game on Wednesday afternoon.
49ers remaining schedule 2025
| Date | Opponent | Time | TV Channel |
| 10/2 | @ Rams | 8:15 p.m. | Prime Video |
| 10/12 | @ Buccaneers | 4:25 p.m. | CBS |
| 10/19 | vs. Falcons | 8:20 p.m. | NBC |
| 10/26 | @ Texans | 1:00 p.m. | Fox |
| 11/2 | @ Giants | 1:00 p.m. | CBS |
| 11/9 | vs. Rams | 4:25 p.m. | Fox |
| 11/16 | @ Cardinals | 4:05 p.m. | Fox |
| 11/24 | vs. Panthers | 8:15 p.m. | ESPN |
| 11/30 | @ Browns | 1:00 p.m. | CBS |
| 12/14 | vs. Titans | 4:25 p.m. | Fox |
| 12/22 | @ Colts | 8:15 p.m. | ESPN |
| 12/28 | vs. Bears | 8:20 p.m. | NBC |
| TBD | vs. Seahawks | TBD | TBD |
After the 49ers’ Week 5 game against the Rams, San Francisco has a mini-bye before traveling to play the Tampa Bay Buccaneers in Week 6. The 49ers are set to begin a stretch in which they play four road games over the next five weeks, beginning with this week’s matchup in Los Angeles.
