The 49ers will be without one of their best players for the foreseeable future.
Star tight end George Kittle was been ruled out for the remainder of the Week 1 game against the Seattle Seahawks due to a hamstring injury. The injury occurred in the second quarter as San Francisco hoped the injury wasn’t too serious.
Kittle had already scored a touchdown in the game as he caught a five-yard pass from his quarterback Brock Purdy. The tight end was one of the healthiest players on the offense, as running back Christian McCaffrey and the wide receiver room have been dealing with injuries all preseason, leading up to Week 1.
There’s Kittle. In the end zone 😤
📺: FOXNFL+ // https://t.co/KTh0i4oaLh pic.twitter.com/BzYOg5f80b
— San Francisco 49ers (@49ers) September 7, 2025
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Here are the latest injury updates for Kittle.
George Kittle injury updates
Kittle was ruled out for the remainder of the 49ers’ Week 1 game due to a hamstring injury. It was tough to tell where Kittle’s injury occurred. After he scored his touchdown, he spiked the football in the endzone and appeared fine.
Kittle spikeeee 🙌#ForTheCelly x @budlight pic.twitter.com/6sMqKzgThs
— San Francisco 49ers (@49ers) September 7, 2025
Purdy was sacked in the second quarter. After the play, Kittle came over to the sideline and went right into the medical tent. When he emerged, he put on a 49ers hat instead of his helmet, and the TV broadcast of the game broke the news that he wasn’t even questionable to return, but was instead ruled out.
This was the play where Kittle got hurt, but you can’t really tell what happened to him. If the injury really did occur when Purdy was sacked, this was the lone sack he took in the first half.
Julian Love brought PRESSURE. 💥
📺: FOX pic.twitter.com/2fiYuscN07
— Seattle Seahawks (@Seahawks) September 7, 2025
While not the absolute worst news possible, the 49ers got bad news on the Kittle front. The star tight end will miss multiple weeks due to his hamstring injury, per Adam Schefter.
On Tuesday, the 49ers decided to place Kittle on injured reserve, meaning he will miss each of the next four games.
Sources: 49ers are placing Pro Bowl TE George Kittle on injured reserve, meaning he now will miss at least the next four games. Kittle injured his hamstring during Sunday’s win over Seattle and now will miss games at New Orleans, vs. Atlanta, Jacksonville and at the Rams. pic.twitter.com/f73zf9tjcZ
— Adam Schefter (@AdamSchefter) September 9, 2025
George Kittle stats today
With Kittle ruled out for the remainder of the game, here are his final Week 1 stats.
- Targets: 4
- Receptions: 4
- Receiving Yards: 25
- Touchdowns: 1
MORE NFL: Why did Dolphins bench Tua Tagovailoa in Week 1?
49ers TE depth chart
With Kittle out, here is who quarterback Brock Purdy will rely on to fill-in at tight end.
| Position | Name |
| 1 | George Kittle |
| 2 | Luke Farrell |
| 3 | Jake Tonges |
Purdy making magic happen 🪄
Jake Tonges with the hands 🙌
📺: FOXNFL+ // https://t.co/KTh0i4oaLh pic.twitter.com/26IBNBe9MT
— San Francisco 49ers (@49ers) September 7, 2025
MORE NFL: Aaron Rodgers gets his revenge on the Jets, beating them in Week 1
49ers upcoming schedule
Here’s a look at the 49ers next five games.
| Week | Opponent |
| 2 | at Saints |
| 3 | vs. Cardinals |
| 4 | vs. Jaguars |
| 5 | at Rams |
| 6 | at Buccaneers |
George Kittle fantasy football replacements
Losing Kittle is going to hurt fantasy football managers. Las Vegas Raiders tight end Brock Bowers was the consensus top tight end, followed by Arizona Cardinals tight end Trey McBride and Kittle. The San Francisco tight end had an average draft position (ADP) of 34th overall, which in a 12-team league would be a back-end of the third round pick. That is high draft capital to not be able to use for three to five weeks.
You aren’t going to be able to find a direct replacement that will re-capture that value, and you will have to look for upside on the waiver wire.
Here are some options you can look at on waivers to help ease the blow of Kittle’s injury.
| Player | Roster % (Yahoo) | Week 1 stats |
| Hunter Henry, Patriots | 59% | 8.6 FP – 4 receptions, 66 yards |
| Zach Ertz, Commanders | 51% | 10.1 FP – 3 receptions, 26 yards, TD |
| Jonnu Smith, Steelers | 31% | 10 FP – 5 receptions, 15 yards, TD |
| Juwan Johnson, Saints | 2% | 11.6 FP – 8 receptions, 76 yards |
Find more Kittle fill-ins in our Week 2 fantasy waiver wire.
This article will be updated.
